Non-invasive focalized stimulation in deep brain using the spatially symmetric array

As a non-invasive neuromodulation technology, transcranial magnetic stimulation (TMS) shows great potential in the treatment of mental diseases. Using TMS to stimulate deep brain targets has significant scientific research value for exploration causes psychiatric However, focalized induced electrical field (E-field) generated by traditional coils or coil arrays is largely restricted superficial cortical targets. To achieve brain, novel spatially symmetric array based on curved θ-type (the θ-SSA) proposed this paper. Four are symmetrical YZ and XZ planes. Each placed tangent human scalp bent away from head reduce non-longitudinal component accumulation E-field enhance focalization. The finite-element method used obtain 3D spatial distributions intracranial array. Results show that θ-SSA can form an obvious focusing area 11 cm below scalp. Under identical current excitation, increase longitudinal attenuation ratio 77% compared coil. In addition, when generating same area, depth 1.67 times deeper than Meanwhile, dynamically steer stimulated coordinates target point be flexibly continuously adjusted changing parameters applied An anatomically realistic model with gray matter employed paper verify our method.